Introduction

General information

Name & Family name:         Hossein Mirkhani
Date and place of birth:         Oct 24, 1966, Tehran, Iran
Nationality:            Iranian
Marital status:             Married
Address:             
Postal address:        Department of Pharmacology
School of Medicine
Zand Blvd.
Shiraz 71348-53185, Iran
Phone:            +98-711-2305884
            +98-711-2305886
Ext.:3354
Fax:        +98-711-2307591
E-mail:            این آدرس ایمیل توسط spambots حفاظت می شود. برای دیدن شما نیاز به جاوا اسکریپت دارید


Education

                1992-1998             Ph. D. in Pharmacology,
                                                                                                          Iran University of Medical Sciences, tehran, Iran

1985-1991    Doctor of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


Position

1999-2006: Assistant Professor, Department of Pharmacology, Medical School,
Shiraz University of Medical Sciences, Shiraz, Iran

2006-         : Associate Professor, Department of Pharmacology, Medical School,
Shiraz University of Medical Sciences, Shiraz, Iran


Experience    

Cardiovascular Pharmacology: The effects of cardiovascular drugs on isolated tissues in normal and pathological states


Publications


    •    Talebianpoor MS, Mirkhani H. The effect of tempol administration on the aortic contractile responses in rat preeclampsia model. ISRN Pharmacol. 2012; 187208. Epub 2012 Sep 3.
    •     Aliabadi E., Mehranjani M. S., Borzoei Z., Talaei-Khozani T., Mirkhani H., Tabesh H. Effects of L-carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality. Iran. J. Reprod. Med. 2012; 10: 77-82
    •    Vessal G., Khabiri A., Mirkhani H., Cookson B. D., Askarian M. Study of antibiotic prescribing among dental practitioners in Shiraz, Islamic Republic of Iran. East. Mediterr.Health J. 2011; 17: 763-769.
    •    Bagheri M., Jahromi B. M., Mirkhani H., Solhjou Z., Noorafshan A., Zamani A., Amirghofran Z. Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats. J. Surg. Res. 2011; 169: e101-107

    •    Mesbah F., Bahri A., Ghasemi E., Khozani T. T., Mirkhani H., Parsanezhad M. E. The effects of metformin on ovum implantation and pregnancy outcome in rats with induced PCOS. Tehran Univ. Med. J. 2011;  69: 191-197
    •    Noorafshan A, Karbalay-Doust S, Valizadeh A, Aliabadi E, Mirkhani H. Ameliorative effects of curcumin on the seminiferous epithelium in metronidazole-treated mice: a stereological study. Toxicol.  Pathol. 2010;  38: 366-71.
    •    Mesbah F., Moslem M., Vojdani Z., Mirkhani H. Estradiol induced polycystic ovary syndrome: an animal study. Armaghan-e Danesh 2010; 15: 325-334
    •    Davarmanesh M., Mardani M., Mirkhani H., Monabbati A.,Tanideh N., Mehrabani D. Effect of dexamethasone premedication on oral mucositis in hamster. J. Appl. Animal Res. 2009; 36: 267-270
    •    Mirkhani H., Fadakar P. Knowledge, Attitude and practice of physicians in appropriate prescription of organic nitrates in Iran. Iranian J. Pharmacol. Ther. 2009;  8: 83-86
    •    Mirkhani H., Shafa M., Khazraei H. Comparison of the effects of levosimendan and papaverine on human internal mammary artery and saphenous vein. Cardiovas. Drugs Ther. 2009; 23: 355-359
    •    محمدشریف طالبیان‌پور، حسین میرخانی.  اثرات فنیل‌افرین، کلسیم، استیل‌کولین و دیازوکساید بر آئورت مجزای موش‌های صحرایی پری‌اکلامپتیک. ارمغان دانش (1388) شماره 54، صفحه 29-17 . (Talebianpoor M.S., Mirkhani H. Effects phenylephrine, calcium acetylcholine and diazoxide on isolated aorta of preeclamptic rats)
    •    امین کوهپایه، حسین میرخانی، علی اکبر نکوئیان، دیوید سنت.  تعیین تأثیر هسپریدین بر اختلال عملکردی قلب ناشی از دیابت نوع 1 در موش‌های صحرایی. ارمغان دانش (1388) شماره 53، صفحه 35-25. (Kouhpayeh A. Mirkhani H., Nekooeian A.A., Saint A. The effects of hesperidine, on cardiac dysfunction of experimental type-I diabetic rats)
    •    صدیقه شایق، حسین میرخانی، لیلا بذر افکن. دیدگاه دانشجویان دانشگاه علوم پزشکی شیراز در مورد تاثیر برنامه روز معرفی دانشگاه بر انتخاب رشته تحصیلی. گام های توسعه در آموزش پزشکی (1388)، مجلد 6، صفحه 49-40
    •    Samzadeh-Kermani A., Shafaroodi H., Miri R., Mirkhani H., Vosooghi M., Shafiee A. Lipophilic 2-(4-chlorophenyl)-4-thiazolyl-1,4-dihydropyridines: synthesis, calcium channel antagonist activity, and protection against pentylenetetrazole-induced seizure. Medicinal Chem. Res. 2009; 18: 112-126
    •    Miri R., Javidnia K., Mirkhani H., Kazemi F., Hemmateenejad B, Edraki N., Mehdipour, A.R. Synthesis and in vitro dual calcium channel antagonist-agonist activity of some 1, 4-Dihydo-2,6-dimethyl-3-nitro and cyano-4-(1-methyl-5-nitro-1H-imidazol- 2-yl)-5-pyridinecarboxylates. Daru 2008; 16: 263-270
    •    Mesbah S. F., Shokri S., Karbalay-Doust S., Mirkhani H. Effects of nandrolone decanoate on ultrastructure of testis in male adult rats. Iran. J. Med. Sci. 2008; 33: 94-100
    •    Kouhpayeh A., Mirkhani H., Nekooeian AA. Improvement of endothelium-dependent relaxation of rat models type 1 and type 2 by hesperidine. Iran. Cardiovasc. Res. J. 2008; 1: 200-207
    •    Hosseini M., Miri R., Amini M., Mirkhani H., Hemmateenejad B., Ghodsi S., Alipour E., Shafiee A. Synthesis, QSAR and calcium channel antagonist activity of new 1,4-dihydropyridine derivatives containing 1-methy 1-4,5-dichloroimidazolyl substituents. Archiv. Pharmazie. 2007; 340: 549-556
    •    Mesbah S. F., Shokri S., Karbalay-doust S., Mirkhani H. The effect of nandrolone decanoate on the body, testis and epididymis weight and semen parameters in adult male rat. Iran. J. Med. Sci. 2007; 32: 93-99
    •    Miri R., Javidnia K., Mirkhani H., Hemmateenejad B., Sepeher Z., Zalpour M., Behzad T., Khoshneviszadeh M., Edraki N., Mehdipour A. R. Synthesis, QSAR and calcium channel modulator activity of new hexahydroquinoline derivatives containing nitroimidazole. Chem. Biol. Drug Des. 2007; 70:329-36
    •    Karbalay-Doust S., Noorafshan A., Ardekani F. M., Mirkhani H. The reversibility of sperm quality after discontinuing nandrolone decanoate in adult male rats. Asian J. Androl. 2007; 9: 235-239
    •    Daryabari N., Akbarzadeh T., Amini M, Miri R., Mirkhani H., Shafiee A. Synthesis and calcium channel antagonist activities of new derivatives of dialkyl 1,4-dihydro-2,6-dimethyl-4-(5-phenylisoxazol-3-yl)pyridine-3,5- dicarboxylates. J. Iranian Chemical Society. 2007; 4: 30-36 
    •    Ghodsi S., Alipour E., Amini M.,  Miri R., Tagi-ganji K. M., Hosseini M., Mirkhani H., Shafiee A.  The synthesis and characterization of new asymmetrical dihydropyridine derivatives containing a 2,4-dichloro-5-thiazolyl substituent. Phosphorus, Sulfur, and Silicon. 2006; 181: 2435-2444
    •    Askarian M., Moravejji A.R., Mirkhani H., Namazi S., Weed H. Adherence to American Society of Health-system Pharmacists (ASHP) surgical antibiotic prophylaxis guidelines in Shiraz, , Iran. Infect. Control Hosp. Epidemiol. 2006; 27:876-878
    •    Mirkhani H., Golbahar J., Shokri S. Chronic administration of nandrolone decanoate does not increase the plasma homocysteine level of male rats. Basic Clin. Pharmacol. Toxicol. 2005; 97: 214-217
    •    Mirkhani H., Dirin M., Youssef-Zayeh I. Mechanism of vasoselective action of mebudipine, a new calcium channel blocker. Vasc. Pharmacol. 2005; 42: 23-29
    •    Mirkhani H., Omrani G. R., Ghiaee S., Mahmoudian M.  Effects of mebudipine and dibudipine, two new calcium channel blockers, on rat left atrium, rat blood pressure and human internal mammary artery. J. Pharm. Pharmacol. 1999; 51: 617-622
    •    Mahmoudian M., Shafiei M., Mirkhani H., Omrani G. R. Effects of different vasodilators on human internal mammary artery in vitro. Adv. Exp. Med. Biol.1999;  471: 419-426
    •    Mahmoudian M., Mirkhani H. Effect of diazoxide, an ATP-dependent potassium-channel opener, on isolated aortae of normal and diabetic rats. Gen. Pharmacol. 1998; 31: 569-571
    •    Mahmoudian  M., Mirkhani H., Nehardani Z., Ghiaee s. Synthesis and biological activity of two new calcium-channel blockers, mebudipine and dibudipine. J. Pharm. Pharmacol. 1997; 49: 1229-1233


Books
Drug dosage forms and proper use of them (Persian)
1st edition, 2009
Limia publications, Tehran, Iran
http://nashr.sums.ac.ir/view_book.php?book=3086

Presentations

Khazraei H., Shafa M., Mirkhani H. Effect of ranolazine on cardiac microcirculation of normal and diabetic rats, using laser Doppler flowmetry. 6th Middle East Cardivascular Congress, Jan 2012- Dubai, UAE

Khazraei H., Mirkhani H., Shafa, M. Effect of ranolazine on contractility and refractory period of left atrium of normal and diabetic rats. 6th Middle East Cardivascular Congress, Jan 2012- Dubai, UAE

Khazraei H., Mirkhani H. Comparison of the effects of ranolazine on cardiac functional parameters in normal and diabetic rats. 20th Iranian Congress of Physiology  and Pharmacology, Oct. 2011- Hamedan, Iran

Khazraei H., Mirkhani H. Study of the mechanism of vasorelaxant effect of ranolazine on isolated rat aorta. 20th Iranian Congress of Physiology  and Pharmacology, Oct. 2011- Hamedan, Iran

Mirkhani H., Fadakar P, Hojjati H. Effectiveness of common administered doses of glyceryl trinitrate and isosorbide dinitrate in healthy volunteers, using laser Doppler flowmetry. 19th Iranian Congress of Physiology  and Pharmacology, Nov. 2009- Tehran, Iran
 

Mirkhani H., Fadakar P., Knowledge, attitude and practice of general practitioners and specialist doctors of Fars province in rational prescription of organic nitrates in 2002. 18th Iranian Congress of Physiology  and Pharmacology, Aug. 26-30, 2007- Mashad, Iran

Mirkhani H., Miri R., Bagheri A., Calcium channel antagonist activity evaluation of some new dichlorothiazole 1,4-dihydropyridine derivatives by means of guinea-pig ileal smooth muscle. 18th Iranian Congress of Physiology  and Pharmacology, Aug. 26-30, 2007- Mashad, Iran
 
Dirin M., Mirkhani H., Study of the mechanism of vasoselective action of mebudipine, using isolated rat aorta. 14th International Congress of Geographical Medicine & 15th Iranian Congress of Physiology  and Pharmacology, Nov. 5-8, 2001- Shiraz, Iran

Youssef-Zayeh I., Mirkhani H., Chronotropic and inotropic action of mebudipine, a new calcium channel blocker in isolated rat atria. 14th International Congress of Geographical Medicine & 15th Iranian Congress of Physiology  and Pharmacology, Nov. 5-8, 2001- Shiraz, Iran

Mahmoudian M., Motevalian M., Radjaee Behbahany N., Mirkhani H., Rahimi Sharbaf F. Application of human umblical artery in-vitro for evaluation of newly synthesized calcium entry blockers. 12th Iranian Congress of Physiology  and Pharmacology, Nov. 6-9, 1995- Tehran, Iran

Ghaemmaghami M., Tehrani H., Mahmoudian M. Mirkhani H., Zareh A., Akbari A., Daneshmehr M. A. Isolation and purification of toxic peptides from the Iranian scorpion venom, Odontobuthus doriae, and their effects on Guinea pig's heart atrium. 12th Iranian Congress of Physiology  and Pharmacology, Nov. 6-9, 1995- Tehran, Iran

Current activities
Effect of antioxidants on vasculopathies in experimental diabetes and preeclampsia
Pharmacological effects of ranolazine